INCLUDE Grants​

Neurodegeneration in Aging Down Syndrome (NiAD): A Longitudinal Study of Cognition and Biomarkers of Alzheimer's Disease

Christian, Bradley THanden, Benjamin LKlunk, William E

Adults with Down syndrome (DS) are at an extremely high risk for developing Alzheimer's disease (AD), with most individuals over age 40 evidencing neurofibrillary tangles and neuritic plaques (which are thought to be associated with the eventual appearance of AD symptoms). The goal of the current application is to recruit and follow 180 adults with DS and 40 biomarker controls to enable the identification of the longitudinal progression of AD in adults with DS using clinical, cognitive, imaging and genetic and biochemical biomarkers. This data is not only necessary to deepen our understanding of the pathophysiology of AD in DS, but may also offer information that will prove useful in the design of treatment trials to slow or prevent AD in DS.

Down Syndrome Publications​

Neurobiology of aging2021
Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome.
Brain sciences2021
Sleep and White Matter in Adults with Down Syndrome
Brain sciences2021
Acute Regression in Down Syndrome.
The Lancet. Neurology2021
Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study.