Summary
The proposed research is relevant to public health because it interrogates mechanisms of CD4+ T cell dysregulation and of impaired vaccine response in people with Down syndrome. This knowledge would establish the foundation to identify therapies to mitigate immune aging and impaired vaccine response in people, both with and without Down syndrome, with likely utility across a broad spectrum of immune-related conditions. Thus, the proposed research is relevant to the part of NIH's mission pertaining to reducing illness and disability.