Summary
Individuals with Down syndrome are at increased risk of recurrent respiratory infections, including SARS-CoV- 2 infections. The implementation of non-pharmaceutical interventions (NPIs) such as hand washing, social distancing, and face masking during the pandemic has resulted a dramatic global reduction in the incidence of common respiratory virus infections. Through determining the burden of all-cause respiratory morbidity during the pandemic time, the proposed study will provide important information to inform the usage of subsequent vaccines, protection products, and therapeutic strategies to reduce respiratory morbidity in individuals with Down syndrome.