Summary
Adults with Down syndrome are at high risk of developing Alzheimer’s disease. The parent R01 addresses this public health crisis by investigating the effect of modifiable aspects of lifestyle (physical activity, sleep, cognitive stimulation, and social engagement) on biomarkers of Alzheimer’s disease and cognitive decline in adults with Down syndrome. This supplement builds on this effort by increasing the sample size and diversity and employing new innovative mediational analyses and methods for non-invasive biomarkers of sleep and physical activity in everyday life.